Long-Term Melatonin Use May Pose Heart Risks
Recent research has uncovered potential dangers linked to prolonged melatonin use for sleep disorders. A study revealed that chronic melatonin users were nearly twice as likely to die and 3.5 times more likely to be hospitalized due to heart failure.
Increased Heart Failure Risk Among Chronic Users
A preliminary study presented at the American Heart Association's Scientific Sessions 2025 showed that adults with chronic insomnia taking melatonin for a year or more faced higher risks of developing heart failure, hospitalization from the condition, and death from any cause compared to non-users.
The study was shared during the AHA's annual meeting held from November 7-10 in New Orleans, an important global event for updates on cardiovascular science and clinical research.
About Melatonin
Melatonin is a hormone produced by the pineal gland that controls the sleep-wake cycle, increasing in darkness and decreasing during daylight. Synthetic melatonin, identical to the natural hormone, is widely used to manage insomnia and jet lag.
Supplement Regulation and Usage
Melatonin supplements are sold over the counter in many countries, including the U.S. However, they are unregulated in the U.S., which means the purity and dosage can vary significantly between products.
Expert Advice
Although generally considered safe, experts now recommend caution with long-term melatonin use due to these unexpected cardiovascular risks.
Summary: New findings suggest that extended melatonin use for sleep issues may significantly raise the risk of heart failure and mortality, urging careful consideration before long-term use.
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