Three infections, one fight: an implementation study to map needle prevalence and evaluate HIV, syphilis and hepatitis C prevention interventions in Regina, Saskatchewan – a protocol

Three infections, one fight: an implementation study in Regina, Saskatchewan

Introduction

Saskatchewan is currently facing a public health crisis marked by high rates of HIV, syphilis, and hepatitis C virus (HCV) infections, mostly affecting people who use injection drugs. These overlapping epidemics are worsened by structural challenges such as stigma, poverty, and a lack of culturally safe healthcare. There is an urgent need for innovative, community-driven strategies to enhance prevention, testing, and linkage to care.

Methods and Analysis

This study introduces a rapid assessment and response system in Regina, integrating geospatial mapping of needle distribution with community pop-up interventions. Maps highlighting needle hotspots will guide the placement of pop-up events offering on-site testing for HIV, syphilis, and HCV, as well as education on pre-exposure prophylaxis (PrEP) and postexposure prophylaxis (PEP).

A convergent participatory mixed-methods approach will evaluate the program’s feasibility, acceptability, and effectiveness, using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework.

Quantitative Assessment

Qualitative Substudy

Includes 30 participants to explore their experiences with the intervention, identify barriers to care, and understand perceptions of service delivery.

Saskatchewan is facing a public health crisis driven by high rates of HIV, syphilis, and hepatitis C virus (HCV) infections, particularly among people who use drugs.
Needle hotspot maps will guide deployment of community-based pop-up events offering point-of-care testing and education on PrEP and PEP.

Summary: This study tackles interconnected infections through targeted, community-led interventions in high-risk areas, aiming to improve prevention and care among vulnerable populations in Regina.

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BMJ Open BMJ Open — 2025-11-05