Caspase-9 as a Potential Target for Pulmonary Fibrosis Treatment
Researchers have identified caspase-9, an enzyme involved in cell death, as a potential target for treating pulmonary fibrosis, according to a preclinical study.
The study found that blocking caspase-9 eased fibrosis in mice and cell models, suggesting a new approach to halting or reversing tissue scarring in pulmonary fibrosis (PF).
Blocking caspase-9 — an enzyme involved in programmed cell death, or apoptosis — may halt or reverse tissue scarring in pulmonary fibrosis (PF).
- Elevated levels of caspase-9 were found in lung tissue from people with PF and in a mouse model of the disease.
- Caspase-9 activity was localized to diseased areas.
- Blocking caspase-9 reduced signs of cell death and lung fibrosis in the PF mouse model.
Caspase-9 promotes lung fibrosis by triggering apoptosis and activating beta-catenin signaling.
Author's summary: Caspase-9 is a potential target for treating pulmonary fibrosis.
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