In a First, Scalable Production of Human Kidney Organoids Using Perfused Pig Kidneys

Breakthrough in Human Kidney Organoids Production

A novel technique has been developed to generate human kidney organoids in a scalable manner.

By integrating human kidney organoids into perfused pig kidneys, researchers have created a pioneering technology that enables the production of these organoids on a larger scale.

“Systematic production of human kidney organoids for transplantation in porcine kidneys during ex vivo machine perfusion.”

This innovative approach, published in Nature Biomedical Engineering, allows the organoids to be combined with ex vivo pig kidneys and then transplanted back into the same animal to evaluate their viability.

The findings mark a significant milestone in regenerative and personalized medicine, paving the way for the use of kidney organoids derived from human stem cells in cell therapy clinical trials.

Author's summary: Scalable human kidney organoids production achieved.

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GEN - Genetic Engineering and Biotechnology News GEN - Genetic Engineering and Biotechnology News — 2025-11-01

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