NFL Picks and Predictions for Week 6
The NFL season continues with a highly anticipated slate of games in Week 6. Here are 3 plus-money bets to consider.
By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT
Week 6 Predictions
Last week's NFL bold predictions went 2-1, resulting in a +1.17 unit overall gain. Since Week 3, picks in this story are up 2.16 units.
This Week's Picks
- Fading the Colts offense, despite their current average of 3.39 points per drive, which would be the highest this century if maintained all season.
Indianapolis is currently averaging 3.39 points per drive.
Author's summary: NFL Week 6 picks and predictions.
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